28 سنوات
Thanks dr. ,..please would u inform.me.exacy how do cdpxan work? On brain..pschological impacts? I used to take effexor in.it worked.on brain.but valdoxan how xacy nd where it works
16 أغسطس 2014
This results in the release of norepinephrine and dopamine (the drug does not affect serotonin levels.
The melatonergic function appears to improve sleep patterns, whereas the serotonergic antagonism results in the release of norepinephrine and dopamine. Given the current information, the overall side-effect profile of agomelatine appears relatively mild. For example, agomelatine has no discontinuation syndrome, exhibits infrequent sexual dysfunction, and is generally weight neutral
Treatment with the drug increased slow wave sleep without modification of REM (Rapid Eye Movement) sleep amount or REM latency. Agomelatine also induced an advance of the time of sleep onset and of minimum heart rate. From the first week of treatment, onset of sleep and the quality of sleep were significantly improved without daytime clumsiness as assessed by patients.
However, this antidepressant may cause elevations in hepatic enzymes,a finding that warrants further investigation so the doctor may order liver tests prior to treatmnet with it and further follow ups after .
If you are using or you had used effexor medication here is a brief comparison in between voldaxon and effexor in case of efficacy:
Effexor (venlafaxine) is an antidepressant in a group of drugs called selective serotonin and norepinephrine reuptake inhibitors (SSNRIs). Venlafaxine affects chemicals in the brain that may become unbalanced and cause depression.
>Valdoxan has shown earlier symptom improvement compared with effexor(venlafaxine 75-150 mg), with twice the number of responders as venlafaxine and sertraline.
>Three pivotal studies have evidenced Valdoxan’s efficacy versus after 6 to 8 weeks on all core symptoms of depression, as well as its superiority to venlafaxine .
>It has negligible affinity for all other central receptors and transporters ,It does not influence brain serotonin levels as with SSRIs, SNRIs, or TCAs. This unique receptor profile enables Valdoxan to re synchronize circadian rhythms and show antidepressant efficacy .
>Agomelatine appears to cause fewer sexual side effects and discontinuation effects than paroxetine. It appears better tolerated than the SSRI
As a conclusion ,check with your doctor for what is best for you ,in general valdoxon is anew drug treatment for major depression disorder affects receptors without affecting central receptors and serotonin uptake ,it increases noradrenaline and dopamin in the frontal cortex and had good sleep issues in comparison to other ssnri one of them being effexor.
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